The radiation therapy oncology group has completed 2 trials rtog 0614 and 0933 aimed at reducing the toxicity of wbrt. Rtog 0529, a phase ii evaluation of dosepainted imrt in combination with 5fluorouracil and mitomycinc for reduction of acute morbidity in carcinoma of the anal canal. It is intended to be used only in conjunction with institutionspecific irb approval for study entry. History of prior rtog studies two successive randomized btsg studies, 6901 and 7201 demonstrated superior survival for patients with malignant glioma receiving whole brain rt to 60 gy in single 1. Clinical stage t1t4 n0n3 anal cancer patients were submitted to concomitant chemoradiation. The management of lung cancer american society for. Rtog 0529 was a phase 2 study of 52 anal cancer patients prospectively treated with dose. Jun 08, 2011 rtog 0924 cdr0000701128 nci201102674 registry identifier. Dosimetric evaluation of heterogeneity corrections for rtog 0236. Standarddose versus highdose conformal radiotherapy with. Sorafenib tosylate with or without stereotactic body. A randomized, phase iii, doubleblind, placebocontrolled trial of memantine for prevention of cognitive dysfunction in patients receiving wholebrain radiotherapy nadia n.
The rtog 9208 phase 2 trial exploring dose escalation included a 2. Longterm results of rtog 0236 confirm good primary tumor. Radiation oncologytoxicity gradingrtog wikibooks, open. Preliminary results of a phase ii study of a temozolomide tmz and radiotherapy rt in high risk low grade gliomas lggs find. Recently published results from the longterm followup of radiation therapy oncology group rtog trial 9802 demonstrated medically meaningful. A phase ii evaluation of dose painted imrt in combination with 5fluorouracil and mitomycinc.
In this study for highrisk pca gleason 89 or high psa half of us got 2 months of lupron plus casodex, followed by 8 weeks 40 days of rt plus lupron, followed 1 month later by 2 years of lupron and up to 6 cycles of docetaxel. Pmid 11702729 2001 rtog publications since 1996 ijrobp vol 51 no 3 suppl 2, 125145, 2001. Vs is an important postradiation treatment toxicity because fibrosis of the vaginal canal may limit the ability of patients to tolerate pelvic examinations needed for future cancer surveillance, and it may also negatively affect patients sexual function and quality of life. Concurrent chemotherapy and intensity modulated radiation. One of those trials is radiation therapy oncology group rtog protocol 9508, which was a phase 3 randomized trial of whole brain radiation therapy wbrt versus wbrt and stereotactic radiosurgery srs. Recent series have demonstrated an association with. This is an ascii program runs in a winterm or xterm window with a keyboard interface and commands, in windows a command prompt window and is invoked with the flag d followed by the directory where the rtog files are for the particular patient. Cystic lymph node metastases from hpvassociated squamous. Kachnic la1, winter k, myerson rj, goodyear md, willins j, esthappan j, haddock mg, rotman m, parikh pj, safran h, willett cg. This site will allow users to register a patient or enter case form data directly to a nrgrtog study twentyfour 24 hours a day, seven 7 days a week. Secondary analysis of rtog 9508, a phase 3 randomized. There is consequently an increasing interest in organ preservation and nonsurgical management strategies. Laack, ms, md this trial was conducted by the radiation therapy oncology group rtog, and.
Pelvic irradiation with concurrent chemotherapy versus pelvic. Radiation oncologyrtog trials wikibooks, open books for an. Secure upload to atc advanced technology qa center. Results of rtog 0529, a phase ii protocol investigating imrt use for anal squamous cell carcinoma, confirmed significant reduction in grade 2 and grade 3 toxicity. Find, read and cite all the research you need on researchgate. Mitomycin or cisplatin chemoradiation with or without. Aug 30, 2017 to report on clinical outcomes of simultaneous integrated boost intensity. Imrt pelvic radiation for postoperative treatment of endometrial and cervical cancer timec fast facts patient selection conditions for patient eligibility 3. A phase ii evaluation of dosepainted imrt in combination with 5fluorouracil and mitomycinc for reduction of acute morbidity in carcinoma of the anal canal. Calgb 30610 rtog 0538 limited small cell 45 gy bid 3 weeks 61. Radiation therapy with or without chemotherapy in treating patients with highrisk malignant salivary gland tumors that have been removed by surgery the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Ctrp clinical trial reporting program u10ca021661 u. Dosimetric evaluation of heterogeneity corrections for.
These times are comparable to those demonstrated in rtog 0529 median. Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamouscell carcinoma of the anus act ii. Ultimately, the results of the rtog 0529 phase 2 trial will provide prospective data on rates of acute toxicity in patients treated with imrt and concurrent 5. Mild tightness of skin and itching may occur to promote hydrated skin, patient comfort and maintain skin integrity. Rtog 0529 protocol reporting on pattern of failure, clinical outcomes. Nrg oncology study terminations effective december 15, 2016 please see the link below for nrg oncology studies that will be terminated as of 5 pm est today, thursday, december 15, 2016. Please visit the rtog website for the latest trials and protocol information. Clinical and treatment factors associated with vaginal.
Radiation therapy oncology group rtog 0618 a phase ii trial of stereotactic body radiation therapy sbrt in the treatment of patients with operable stage iii nonsmall cell lung cancer study chairs 2409 principal investigatorradiation oncologyigrt robert d. Patients with the following pathology findings may be treated with pelvic radiation with or without weekly cisplatin at the treating physicians discretion. In addition to radiation dose to pelvic bone marrow, baseline anc was the only significant predictor of hematologic toxicity on multivariable analysis and was included in all models. Vaginal stenosis vs is defined as vaginal shortening andor decreased width of the vaginal canal. That study showed a survival advantage for patients with 1 brain metastasis treated with wbrt and srs versus wbrt alone but no such advantage.
University of texas southwestern 5801 forest park road, nf3. This is a pdf file of an unedited manuscript that has been accepted for publication. Radiation therapy oncology group rtog and eastern cooperative oncology group ecog with similar findings of improved 1year and median survivals of 60% and. Radiation therapy with or without chemotherapy in treating. Rtog 0236 was a phase ii north american multicenter trial from may 2004 until october 2006 of patients age 18 and older with biopsyproven peripheral t1.
Rtog 0614 was a randomized trial of wbrt versus wbrt and memantine in patients with brain metastases and showed better cognitive function over time in the memantine group. Androgendeprivation therapy and radiation therapy in. Pdf long term outcomes and toxicities of a large cohort of anal. Radiation and chemotherapy with or without an experimental drug rad001 your doctor may recommend this study following surgery for a high grade primary brain cancer glioblastoma rtog 0925. Impact of facility volume on outcomes in patients with. This is the report of the secondary endpoints estimating longterm efficacy and evaluating late effects.
Secondary analysis of rtog 9508, a phase 3 randomized trial. Kane iii, md medical college of wisconsin roswell park cancer institute. Radiation oncologytoxicityrtog wikibooks, open books. If you would like to utilize this site to register a patient and have not been assigned a login name and password from nrgrtog headquarters, please access the password. Rtog and authors are not responsible for any use of these guidances by third parties. Stereotactic body radiation therapy of inoperable stage iii nonsmall cell lung cancer ying xiao, ph. Jun 17, 20 i also was enrolled in rtog 0521 and received the docetaxel.
Factors increasing the risk of hpv infection andor modulating host response and the persistence of this. Radiation therapy oncology group rtog 0618 a phase ii trial. After coming off the hormone treatments my psa levels were. To report on clinical outcomes of simultaneous integrated boost intensity. This is currently primarily considered when the standard of care. Two important secondary endpoints of rtog 0529 were to evaluate the potential reduction of. Oct 17, 2018 in the rtog 0529 trial, treatment breaks due to toxicity were needed by 49% of those receiving imrt and by 62% of those conventionally treated.
Your doctor may recommend this study if you have a lowgrade primary brain cancer. Nrg about us center for innovation in radiation oncology. Jun, 2018 a multidisciplinary approach, including total mesorectal excision, radiotherapy rt and chemotherapy cht is presently considered the standard of care for the treatment of locally advanced rectal cancer 1,2. Standard total mesorectal excision tme surgery can, however, result in significant morbidity and mortality. If you would like to utilize this site to register a patient and have not been assigned a login name and password from nrg rtog headquarters, please access the password authorization form. Stereotactic body radiation therapy sbrt to treat operable earlystage lung cancer patients asco 20 18gy x 3 33 patients enrolled, 26 evaluable 2year local failure 7. Nvcr announced today that the first patient has been enrolled in the rtog foundations phase 2 pilot trial testing optune together with bevacizumab for patients with bevacizumabrefractory recurrent glioblastoma gbm. I also have been checking for results regarding the trial but, so far, all ive found are minutes that the trial is still being. Pelvic irradiation with concurrent chemotherapy versus. The materials presented on this website illustrate the consensus reached among cooperative groups and disease site committees. In the rtog 0529 trial, treatment breaks due to toxicity were needed by 49% of those receiving imrt and by 62% of those conventionally treated. Os 84% one patient required surgical salvage with lobectomy for recurrence rtog 1021.
Two important secondary endpoints of rtog 0529 were to evaluate the potential reduction of all adverse events with the use of dpimrt, and to assess the investigators ability to perform dpimrt within the radiation planning guidelines delineated. Has the patient had prior systemic chemotherapy for anal cancer. Anal canal cancer is a relatively rare malignancy that frequently presents with metastases to mesorectal, inguinal, femoral, external iliac, and internal iliac lymph nodes. Variability of clinical target volume delineation for rectal. Rtog 0630 radiation therapy oncology group rtog 0630 a phase ii trial of image guided preoperative radiotherapy for primary soft tissue sarcomas of the extremity study chairs principal investigatorradiation oncology surgical oncology cochair dian wang, md, phd john m. Rtog 0529 radiation therapy oncology group rtog 0529 a phase ii evaluation of dosepainted imrt in combination with 5fluorouracil and mitomycinc for reduction of acute morbidity in carcinoma of the anal canal study chairs principal investigatorradiation oncology lisa kachnic, md boston university medical center 88 east newton street, eb 11. A phase h study of preoperative preop chemoradiotherapy crt utilizing imrt in combination with capecitabine c and. Nrg oncology covid19 updates all of our sdmc and operations center staff have shifted to work remotely, and remain here to serve you. Radiotherapy for rectal cancer has traditionally been used in the neoadjuvant setting, prior to radical surgery. No other use or reproduction is authorized by rtog nor does rtog assume. Rtog is funded by national cancer institute grant numbers. Squamous cell carcinoma of the anus scca is strongly associated with human papillomavirus hpv infection which represents the causative agent in 80%85% of patients usually from hpv16 or hpv18 subtypes in europe as is its precursor lesion anal intraepithelial neoplasia ain 3.
Jan 07, 20 recently published results from the longterm followup of radiation therapy oncology group rtog trial 9802 demonstrated medically meaningful and statistically significant survival prolongation. Preoperative rt is a wellestablished option to provide tumor downsizing and downstaging and to increase locoregional control in this setting 3. Rtog manuscripts and abstracts submitted for publication. Rtog 0529 was a phase 2 study of 52 patients with anal cancer who were prospectively treated with dosepainted intensity modulated radiation therapy.
158 886 531 1350 956 1283 1545 1143 1310 1488 868 830 511 1445 458 277 596 1100 765 1551 437 670 1493 1511 809 607 217 158 844 578 751 257 842 1277 108